The functional implications of this increase in the number of mature oligodendrocytes are yet to be clarified given that other markers of myelination (e.g., PLP, CNP, MAG, MOG, MOBP) were unaffected by or even decreased (e.g., MBP) in both DS-EA and DS groups compared to the control groups (Tanti et al., 2018), see also Figure 4. This evidence concerns the gene CNP and Dravet syndrome.