RTN4 and Dravet syndrome: Reduced density of Olig2 (a general marker of OL) and increased density of Nogo-A, APC, Mash1 (markers of mature OL) in DS-EA compared to DS and CTL groups with some evidence that these effects were more pronounced in younger individuals. DS-EA and DS groups show reduced MBP levels but there was no effect of EA on any markers of myelination (e.g., PLP, CNP, MAG, MOG, MOBP). The authors propose that EA causes precocious maturation of OPC in the prefrontal cortex.