ABCA7 and Alzheimer disease: Of note, accumulating genetic evidence collected through genome-wide studies (GWASs) has confirmed ABCA7 variants to be late-onset AD susceptibility loci, which include rs3764650, rs3752246, and rs115550680 (Hollingworth et al., 2011; Naj et al., 2011; Guerreiro et al., 2013; Jonsson et al., 2013).