GRIN2A and neurodevelopmental disorder: It has been shown that mutations in grin2A induced a decrease in GluN2A expression and led to complex neurodevelopmental disorders that include the occurrence of seizures (Endele et al., 2010; Lemke et al., 2013; Pierson et al., 2014; Yuan et al., 2014; Burnashev and Szepetowski, 2015; Swanger et al., 2016; Addis et al., 2017; Sibarov et al., 2017; Cardis et al., 2018; Punnakkal and Dominic, 2018; Strehlow et al., 2019; Amador et al., 2020; Mota Vieira et al., 2020).