RYR2 and epilepsy: Taken together the facts that RYR-2 is highly expressed in the brain (Martin et al., 1998) and that RYR2 knockout animals presented increased cellular excitability (Loaiza et al., 2013; Liu et al., 2014; Choy et al., 2016; Dickinson et al., 2016; Seidel et al., 2020), it is considered that RYR2 gene is potentially a candidate pathogenic gene of epilepsy.