Notably, our results indicated that the depletion of glucose and serum levels significantly induced inflammation in adipocytes, which was consistent with a previous study illustrating the effect of low glucose on the proinflammatory cytokine IL-1β level in monocytes [27] and hypoglycaemia induced increase in proinflammatory cytokines (TNFα, IL-1β, IL-6, and IL-8) and oxidative stress in healthy individuals [28]. Here, TNF is linked to Hypoglycemia.