Third, adipose tissue synthesizes hormones and signaling peptides known as adipokines that include leptin, adiponectin, chemerin, tumor necrosis factor-α, interleukin-6, interleukin-10, and monocyte chemoattractant protein-1, contributing to the inflammatory response in obesity-related glomerulopathy [24,25]. Here, RARRES2 is linked to obesity due to melanocortin 4 receptor deficiency.