A serial analysis of gene expression (SAGE) data for HDAC6 suggests that HDAC6 is minimally express in normal kidney tissues [30], however, the level of HDAC6 expression is up-regulated in various kidney diseases, such as autosomal dominant polycystic kidney disease (ADPKD) [31], lupus nephritis [32], and AKI [23]. Here, HDAC6 is linked to autosomal dominant polycystic kidney disease.