IGFBP1 and retinal disorder: In the retina of PACAP-deficient mice with retinopathy, we observed an increase in altogether 11 more factors, including proteins related to extracellular matrix reorganization (i.e., MMP-3, MMP-8), inflammation (i.e., IL-10, IP-10), and growth factors (i.e., FGF-7, IGFBP-1, PIGF-2), and the decrease of 4 proteins, such as CXCL-16, Endoglin, Endothelin-1, and Serpin E1, also known as Plasminogen activator inhibitor-1 (PAI-1) (Fig. 5C).