INS and Hypoglycemia: The accelerated gastric emptying after RYGB and SG determines an increase of GLP-1 release from L-Cell in response to a meal [12, 46], which contributes to the stimulation of the pancreatic beta cell to increase insulin secretion with the consequent tendency to hypoglycaemia observed 2 h after glucose ingestion mostly in patients who underwent RYGB [46] (Fig. 2).