Nonetheless, some of the proteins have been acknowledged for the possible involvement in diabetic retinopathy or ROP: AGER, ANGPT1, CD40LG, GDF2, MMP12, SERPINE1, THBD, DKK1, PDGFA, and IL-18.47,50,51,54,56,58,92,101,114–123 For example, Lamine et al.115 presented recently that CD40LG is associated to both occurrence and severity of type 2 diabetic retinopathy, which shares some physiological connections with ROP. The gene discussed is DKK1; the disease is retinopathy of prematurity.