NFKB1 and COVID-19: Degradation of IκB allows NF-κB translocation to the nucleus to initiate the transcription of downstream genes by binding to specific DNA binding regions.17 Recent single-cell sequencing and RNA-sequencing researches showed that SARS-CoV-2 infection was capable of inducing NF-κB activation in peripheral blood mononuclear cells or bronchoalveolar immune cells from COVID-19 patients or in human respiratory cell lines.3,18–21 However, the mechanisms by which SARS-CoV-2 induces NF-κB activation are yet to be investigated.