KDM6A and cancer: Inactivating mutations and deletions of KDM6A have been identified in a variety of human cancers, including colon, bladder, prostate, and esophageal cancer.21, 22, 23, 24KDM6A featured among the 127 significantly mutated genes in The Cancer Genome Atlas study that analyzed 3281 tumors derived from 12 cancer types.25