In contrast to ceramide that promotes viral infection with SARS-CoV-2, sphingosine (2-amino-4-trans-octadecene-1,3-diol), which is released from ceramide by the activity of neutral, acid, or alkaline ceramidases, was recently shown to exert antiviral activity, either by trapping viruses in endosomes and thereby shuttling them to lysosomal degradation (35) or by competing the binding of SARS-CoV-2 spike to ACE2 (23). This evidence concerns the gene ACE2 and viral infectious disease.