We demonstrated that infection of cultured epithelial cells or freshly isolated human nasal epithelial cells with SARS-CoV-2 or vesicular stomatitis virus (VSV) pseudoviral (pp-VSV-SARS-CoV-2) spike particles, respectively, resulted in activation of the acid sphingomyelinase and release of ceramide (14). This evidence concerns the gene SMPD1 and infection.