While there are multiple pathways through which GGPP depletion can cause apoptotic cell death, we found an upregulation in FASL mediated apoptosis to play a role for growth-inhibitory effects of fluvastatin observed in our SV40C3 TAg mice experiments These results are consistent with the growing evidence that the beneficial effects of statins are beyond cholesterol modulation and partly mediated through isoprenoid inhibition in the setting of neurological disorders and cancers [26–28]. The gene discussed is FASLG; the disease is cancer.