Given current evidence supporting a genetic predisposition for pelvic organ prolapse, we have identified four variants through meta-analysis of candidate gene studies significantly associated with POP (rs2228480 in the ESR1 gene, rs12589592 in the FBLN5 gene, rs484389 in the PGR gene, and rs1800012 in the COL1A1 gene). This evidence concerns the gene FBLN5 and pelvic organ prolapse.