ESR1 and pelvic organ prolapse: Given current evidence supporting a genetic predisposition for pelvic organ prolapse, we have identified four variants through meta-analysis of candidate gene studies significantly associated with POP (rs2228480 in the ESR1 gene, rs12589592 in the FBLN5 gene, rs484389 in the PGR gene, and rs1800012 in the COL1A1 gene).