However, the specific sites for binding among PCSK9, GSTP1, and JNK are unknown, and the role of JNK in PCSK9-mediated inhibition of HCC growth has not been verified, warranting further studies of the interaction domains and the role of JNK in PCSK9-mediated inhibition of HCC growth. The gene discussed is MAPK8; the disease is hepatocellular carcinoma.