EFNA5 and neoplasm: Notably, while EFNA1 depletion clearly reduced tumor-suppressive EphA2-pY588, as expected upon depletion of the ligand-mediated signaling, EFNA5 silencing left EphA2-pY588 essentially unaltered in OVCAR3 and even increased this tyrosine phosphorylated receptor in OVCAR4 (Fig. 2D, E).