To elucidate the possible causative role of LH-R overexpression in the neoplastic transformation leading to the establishment of cancers in the female reproductive system, we generated transgenic (TG) mice which express the human LH-R (hLH-R) under the control of the oviduct-specific glycoprotein (OGP) mouse promoter-1 (mogp-1), and hence overexpress hLH-R in the female reproductive tract. This evidence concerns the gene OVGP1 and cancer.