ADGRL4 and neoplasm: We investigated ADGRL4/ELTD1 receptor signalling and found that ADGRL4/ELTD1 had the lowest GC content in the aGPCR family, did not show canonical GPCR signalling, and induced an endothelial tip-cell phenotype when overexpressed (as occurs in tumour-associated endothelium28).