We did not observe any downstream signalling events in HEK293T, COS-7 or HUVEC cells, indicating that the interaction between ADGRL4/ELTD1 and the JAK/STAT3/HIF-1α pathway is specific for glioblastoma or other cancer cell types and does not apply within endothelial cells. This evidence concerns the gene HIF1A and glioblastoma.