Large-scale state transitions (LST) scores, genomic deletions of over 10 Mb, and a genomics feature of human BRCA1/2 mutant cancers and other cancers with HRD32 were higher in all Brca1/2 and Palb2 null tumors than in p53KO tumors (Fig. 3c), although the differences between P2P or B2P groups and the p53KO group failed to reach statistical significance. The gene discussed is P2RY4; the disease is cancer.