It should be noted, however, while human BRCA1 breast cancers indeed show higher LST scores than BRCA2 and PALB2 cancers49, MET amplification is a rare event in human BRCA1/2 and PALB2 breast cancers based on our analysis of The Cancer Genome Atlas database and our own sequencing datasets (not shown). Here, PALB2 is linked to breast cancer.