BRCA1 and cancer: Large-scale state transitions (LST) scores, genomic deletions of over 10 Mb, and a genomics feature of human BRCA1/2 mutant cancers and other cancers with HRD32 were higher in all Brca1/2 and Palb2 null tumors than in p53KO tumors (Fig. 3c), although the differences between P2P or B2P groups and the p53KO group failed to reach statistical significance.