Predicting the effects of indels can be important for disease-related genes : the four different single amino acid deletions annotated as pathogenic by Clinvar78 in two cancer genes, BRCA1 and P53, and one Alzheimer’s-linked gene, APOE, is in the bottom 25th percentile of predicted deletion effect distributions (Supplementary Fig. 7). This evidence concerns the gene TP53 and cancer.