(Furthermore, our work provides additional support to studies showing a pathogenic role for IL-17a in DSS-induced colitis models57,58) Specifically, our results identify a critical role for miR-146a in limiting IL-17R-mediated tumorigenic signaling by targeting TRAF6, which we show for the first time to our knowledge in IECs in vivo. The gene discussed is TRAF6; the disease is colitis.