Interestingly, our analyses of CRC tissues and IECs from IEC-miR-146a−/− mice (Fig. 4o–r) and miR-146a−/− mice (Supplementary Fig. 4l–o) revealed higher RNA and protein levels of prostaglandin E synthase 2 (PTGES2), a major enzyme involved in PGE2 synthesis, which converts PGH2 to PGE248. The gene discussed is PTGES2; the disease is colorectal carcinoma.