We also confirmed corresponding increases in downstream IL-17R signaling directly within IECs from CRC IEC-miR-146a−/− mice (Fig. 4i) and global miR-146a−/− mice (Supplementary Fig. 4h), as we had observed in CRC tissues from CRC IEC-miR-146a−/− mice (Fig. 4d) and global miR-146a−/− mice (Supplementary Fig. 4c). Here, IL17RA is linked to colorectal carcinoma.