Although treatment with anti-IL-17a rescues CRC severity in IEC-miR-146a−/− mice, it remains possible that other miR-146a-dependent mechanisms independent of IL-17R signaling may contribute to CRC resistance, as effective IL-17 neutralization has been shown to ameliorate CRC across multiple phenotypes5,7,52. Here, IL17RA is linked to colorectal carcinoma.