GABRA2 and Alzheimer disease: Alteration of these genes has been also described in human cases, for example, Gabra2 encodes for the alpha 2 subunit of the GABA receptor (GABAα2), and a recent study in postmortem LOAD cases has shown significant alterations in the GABA receptor expression and currents, including GABAα247, indicating that alterations in the GABA system might be an important contributing factor to the cognitive and synaptic changes observed in AD and in the hAβ-KI mice.