We further sought replication of the association within the CACNB4 gene with cardiovascular disease in FinnGen, a cohort of ~218 K Finnish individuals with an average age of 63, as it includes individuals with a higher average age (63 vs 56 in UK Biobank) and the risk of developing a cardiovascular disease is well-known to increase with age35. The gene discussed is CACNB4; the disease is cardiovascular disorder.