Interestingly, VPS39 expression in muscle biopsies correlated positively with glucose uptake (M-value, r = 0.7015, p = 0.0052) in individuals with T2D (Supplementary Fig. 6a), and there was a non-significant trend to reduced VPS39 expression in muscle from individuals with T2D versus controls (Supplementary Fig. 6b). Here, VPS39 is linked to type 2 diabetes mellitus.