Given the wide range of Aβ plaque and tau tangle burden present in AD patients at autopsy (Braak et al., 2011; Kapasi et al., 2017), it will be informative to expand this technique across multiple sporadic and familial AD donors and to test the hypothesis that various genetic risk factors or specific phenotypes observed at autopsy reflect an endogenous propensity to tau aggregation in neuronal cells. Here, MAPT is linked to Alzheimer disease.