EGFR and non-small cell lung carcinoma: 9-11 Most recently, the ADAURA phase III clinical trial of osimertinib in the adjuvant setting for stage IB, II, or IIIA NSCLC demonstrated significantly improved 2-year disease-free survival of 90% versus 44% in favor of osimertinib.12 Further studies are needed to determine whether this holds true with EGFR inhibition in the neoadjuvant setting.