Since Still’s disease onsets as an autoinflammatory disease, a deeper evaluation of the MoAs of canakinumab (as IL-1 inhibitor) and tocilizumab (as IL6R inhibitor) were performed focusing on the innate immune system effectors (list on supplementary Tables S1-S2, Additional file 2, and Table 2). Here, IL1B is linked to systemic-onset juvenile idiopathic arthritis.