We found significantly higher levels of methylation of the CPEB1 upstream region (located at chr15:83316804–83316986), which is a region close to the CPEB1 promoter (chr15:83316688–83316747), in CRC tumours than that in the accompanying para-tumour tissues (P < 0.0001, Fig. 1c, d). The gene discussed is CPEB1; the disease is neoplasm.