Cytoplasmic polyadenylation element-binding protein 1 (CPEB1) encodes a sequence-specific RNA-binding protein that regulates mRNA polyadenylation and translation [16–18] and has been linked to cancer progression and metastasis [19, 20]. CPEB1 could target the 3′-UTR of SIRT1 mRNA (encoding Sirtuin 1), thereby controlling the length of the poly(A) tail and suppressing its capacity to mediate cancer cell stemness both in vitro and in vivo [21, 22]. The gene discussed is CPEB1; the disease is cancer.