Exceptions to this are CRBN, DDX17, GPER, DISC1, LRP3, and TLR2. Note that DISC1 and TLR2 are on the DisGenet [45] Late onset Alzheimer disease gene set, but that we found no significant enrichment using DisGenet for any method (our test, Limma, Wilcoxon). The gene discussed is GPER1; the disease is early-onset autosomal dominant Alzheimer disease.