Finally, there are several modules related to NOTCH signaling which is also known to play a role in RA [67] (containing the following associated genes NCOR2, HDAC4, HDAC2, SNW1, ERICH1, FBXW7, MIB2, PSEN2, RBPJ, NOTCH4). This evidence concerns the gene HDAC2 and rheumatoid arthritis.