The expression of ZBTB18 has been shown to be negatively regulated by methylation of the CpG island in its promoter region [42] and to reduce proliferation as well as to promote apoptosis in brain tumors such as medulloblastoma (MB) and glioblastoma multiforme (GBM) [42, 43]. This evidence concerns the gene ZBTB18 and glioblastoma.