This is in good agreement with earlier studies showing that CpG island methylator phenotype (CIMP) positive tumors, a subset of colorectal tumors that has high levels of methylation in CpG islands [18], is associated with microsatellite instability, higher BRAF and lower APC and TP53 mutation rates [10, 19, 20]. The gene discussed is APC; the disease is colorectal neoplasm.