ZBTB18 and colorectal cancer: Although ZBTB18 is not frequently mutated in colorectal cancer (0.3–2.5% in large exome sequencing studies [3, 44, 45]), here we found that the expression of ZBTB18 was downregulated by promoter methylation in colorectal cancer cells and that its overexpression reduced their growth both in vitro and in subcutaneous xenograft mouse models.