Overall, our findings support that combination of a subtherapeutic dose of Infliximab, a well-known anti-hTNF agent, with dasatinib, a known small molecule tyrosine kinase inhibitor, shows a strong therapeutic effect in TNF-driven arthritis and we show that, when combined, the two treatments act synergistically to restore, not only clinical, but also molecular arthritogenic profiles, better than standard anti-TNF treatment or treatment with dasatinib alone. Here, TNF is linked to arthritic joint disease.