To further study the potential repositioning of dasatinib and bosutinib for the treatment of arthritis, we took advantage of the hTNFTg mice (Tg197), which spontaneously develop human TNF-driven arthritis pathology [16], similar to that observed in a subset of human RA patients responsive to anti-hTNF treatment [45]. The gene discussed is TNF; the disease is rheumatoid arthritis.