In the present study, we sought to assess the therapeutic potential of dasatinib and bosutinib, in the human TNF-driven Tg197 RA mouse model [16], administered as a monotherapy but also, and in accordance with the clinical practice of administering DMARDs in combination with biologics for the treatment of RA patients, in combination with anti-hTNF biologics. Here, TNF is linked to rheumatoid arthritis.