MMP-12 value of ≥ 4.06 ng/ml is predictive of Oral submucous fibrosis and MMP- 12 value of ≥ 4.21 ng/ml is predictive of Oral squamous cell carcinoma, with 100% sensitivity and 100% specificity (p < 0.001) (Table 5). Here, MMP12 is linked to oral cavity squamous cell carcinoma.