The most important of these complications is the progress of MDS to AML, although it is still unclear whether G-CSF is the cause of this progression or if the increased survival of congenital patients by G-CSF creates an opportunity for this transformation to take place because of the inherent tendency of MDS to progress towards the congenital neutropenic disease called AML [21, 22]. The gene discussed is CSF3; the disease is glycogen storage disease VI.