ERBB2 is overexpressed to varying degrees in many malignancies, such as breast cancer [54], ovarian cancer [55], non-small cell lung cancer [56], and gastric cancer [57]. Besides, ERBB2 is upregulated in high grade gliomas and correlated with PD-L1 expression [58]. The gene discussed is ERBB2; the disease is non-small cell lung carcinoma.