EGFR and non-small cell lung carcinoma: EGFR gene amplification and overexpression can be seen in a variety of human malignancies, including non-small cell lung cancer [47], breast cancer [48], ovarian cancer [49], gastric cancer [50], etc. Abnormal EGFR gene activation is closely related to tumor cell proliferation, angiogenesis, tumor invasion and migration, and inhibition of apoptosis [51].