Multivariate analysis identified eight risk factors that significantly and independently influenced mortality: age ≥ 68 years (P < 0.001), Child–Pugh C cirrhosis (P < 0.001), a history of HCC (P < 0.001), GGT level ≥ 50 U/L (P < 0.001), eGFR < 77.8 mL/min (P < 0.001), serum sodium level < 140 mEq/L (P = 0.0022), platelet count < 8.2 × 103/mm3 (P = 0.0024), and AFP level ≥ 33.9 μg/L (P < 0.001). This evidence concerns the gene AFP and hepatocellular carcinoma.