SERPINE1 and eosinophilic esophagitis: Regarding the concept of platelet activation in EoE, a recent interesting finding may be relevant: Plasminogen activator inhibitor (PAI)-1, a risk factor for thrombosis and the principal inhibitor of urokinase, in turn an activator of plasminogen and hence of fibrinolysis, was reported to be elevated in the epithelium of patients with active EoE [46].