TSC1 and neoplasm: Data from the Broad Institute Cancer Cell Line Encyclopedia (CCLE) [26] was reviewed to identify tumor cell lines with mutations in either TSC1 or TSC2. Among 1457 cell lines, 49 were reported to have mutations in TSC1 and 111 to have mutations in TSC2. These mutations were reviewed to identify those with nonsense mutations, frameshift deletions or insertions, or in-frame deletions in either TSC1 or TSC2, yielding 4 cell lines with probable mutations in TSC1 and 10 with probable mutations in TSC2 (Table 1).