Similarly, the expression of the ligand for Tim-3, CEACAM-1, is increased in colon cancer cells and melanoma cells upon stimulation with IFN-γ [11, 12], and the expression of the ligand for TIGIT, CD155, is induced in endothelial cells after treatment with IFN-γ [13]. This evidence concerns the gene IFNG and malignant colon neoplasm.