In detail, we selected top genes from the dysregulated pool and identified that LIF (Leukemia inhibitory factor), PTBP3 (Polypyrimidine tract binding protein 1), and GHR (Growth hormone receptor) were upregulated while EDNRB (Endothelin receptor type B) and MBP (Myelin basic protein) were downregulated upon ZIKV infection in both MPAs and U251 astrocytes. The gene discussed is PTBP3; the disease is Zika virus infectious disease.