EDNRB promotes reactive astrogliosis and helps in repairing brain injuries (remyelination) [77,78], while MBP releases from a sheath which plays a vital role in compacting myelin and protection of myelin sheath from degradation by myelinotoxic factors (proteinases) produced during multiple sclerosis [79], revealing that these two genes are essential housekeeping factors for normal myelin sheath control. This evidence concerns the gene EDNRB and multiple sclerosis.