In detail, we selected top genes from the dysregulated pool and identified that LIF (Leukemia inhibitory factor), PTBP3 (Polypyrimidine tract binding protein 1), and GHR (Growth hormone receptor) were upregulated while EDNRB (Endothelin receptor type B) and MBP (Myelin basic protein) were downregulated upon ZIKV infection in both MPAs and U251 astrocytes. This evidence concerns the gene GHR and Zika virus infectious disease.