These results indicating that PPARα activator was able to inhibit the expression of CCL2, miRNA-580-5p negatively regulated the PPARα level, and hsa_circ_0110102 functioned as a sponge for miR-580-5p to effect the expression of CCL2 through the activation of PPARα in HCC cells. This evidence concerns the gene PPARA and hepatocellular carcinoma.