rs11770117 (P = 0.03, OR = 1.27 [1.01-1.62]) at IKZF1 locus exhibited independent association with ALL susceptibility even after adjusting for the top signal at IKZF1 locus (i.e., rs11978267, P = 0.003, OR = 1.40 [1.12-1.75]) with Padjust = 0.04, which is consistent with previous observation in Hispanics [8]. This evidence concerns the gene IKZF1 and acute lymphoblastic leukemia.