In pediatric patients, a total of 7 SNPs at 6 loci were significantly associated with ALL susceptibility regardless of molecular subtypes, including SNPs at ARID5B, IKZF1, BMI-PIP4K2A, CEBPE, CDKN2B-AS1, and BAK1 (Table 2). The gene discussed is ARID5B; the disease is acute lymphoblastic leukemia.