Gene mutations or fusions with a good prognosis of AML, such as PML-RARa fusion, NPM1 mutation, AML-ETO fusion, and CBFB-MYH11 fusion, were enriched in COMMD7 low- expression phenotype based on NES, with adjusted P value <0.05 and FDR value <0.05 (Figure 4A–4D). The gene discussed is NPM1; the disease is acute myeloid leukemia.