Finally, further research is needed on the mechanisms of the remaining differentially expressed inhibitors found in this dataset: SFRP4, DKK2, DKK4, APCDD1, and NOTUM. The full elucidation of the mechanisms and pathways of the inhibitors in the Wnt pathway would be a powerful tool for new diagnostics and therapeutics advances in the case of stage IV CRC. This evidence concerns the gene NOTUM and colorectal carcinoma.