These ICDs, together with RT-induced senescence-associated secretory phenotype (SASP), activate T cells and recruit them into tumor sites (Rao and Jackson, 2016; Herrera et al., 2017; Li et al., 2018), whereas interferon gamma (IFNγ) secreted from CD8+ T cells further promotes RT-induced ferroptosis (Lang et al., 2019; Wang et al., 2019b) (Fig. 3A). Here, IFNG is linked to neoplasm.