For example, the cancer stem cell marker CD44 and the deubiquitinating enzyme OTU domain-containing ubiquitin aldehyde binding protein 1 (OTUB1) promote ferroptosis resistance through stabilizing SLC7A11 (Ishimoto et al., 2011; Chew et al., 2017; Liu et al., 2019b). The gene discussed is SLC7A11; the disease is cancer.