TP53 and neoplasm: Notably, several tumor suppressors, including p53, BAP1, ADP-ribosylation factor (ARF), and Kelch-like ECH-associated protein 1 (KEAP1), promote ferroptosis by suppressing the expression or activity of SLC7A11 as part of their tumor suppressive activities (Jiang et al., 2015; Chen et al., 2017b; Fan et al., 2017; Zhang et al., 2018).