BRCA2 and breast cancer: However, it has been reported that some P/LPVs in BRCA2 were more frequent in MBC cases compared to FBC [36, 37], that male carriers of a specific variant had significantly higher lifetime risks of breast cancer compared to other variants in BRCA2 [45] and that large genomic rearrangement in the BRCA2 gene tends to be more frequent in families with MBC cases [46–48].