Recent analyses based on population or registry studies involving many patients showed that BCT is associated with even better OS than mastectomy among patients with early-stage breast cancer.6,7,8,9,10,11,12,13,14,15 By contrast, it is still debated whether BCT could be safely used for BRCA1 (OMIM 113705) and BRCA2 (OMIM 600185) variant carriers with breast cancer. Here, BRCA1 is linked to breast carcinoma.