BRCA1 and invasive breast carcinoma: A total of 8396 patients (mean [SD] age, 50.8 [11.4] years) with primary invasive breast cancer (stages I-III), including 491 BRCA1/2 variant carriers (5.8%) (187 BRCA1 carriers [2.2%] and 304 BRCA2 carriers [3.6%]) and 7905 noncarriers (94.2%), were included in the final analyses.