In a previous report, Santiago et al. [128], Auburger et al. [129], Qu et al. [130], Śnit et al. [131] and Hjortebjerg et al. [132] reported that SLC22A5, SH2B3, ITPR3, CALD1 and IGFBP4 served important roles in type 1 diabetes mellitus, but these genes might be novel target for GDM. This evidence concerns the gene IGFBP4 and diabetes mellitus.