As illustrated in Figure 8, the expressions of HSP90AA1, EGFR, RPS13, RBX1, PAK1 were significantly up-regulated in GDM samples compared with normal, while FYN, ABL1, SMAD3, STAT3 and PRKCA were significantly down-regulated in GDM samples compared with normal. The gene discussed is PAK1; the disease is gestational diabetes.