Increasing evidence indicates that the development of type 2 diabetes mellitus, due to the dysregulation of genes, such as CSNK2A2 [111], NFE2 [112], CAMK2G [113], RASGRP1 [114], S100P [115], SRR (serine racemase) [116], DHPS (deoxyhypusine synthase) [117], DYRK1A [118], JAG1 [119], COL3A1 [120], VTN (vitronectin) [121], WNT3A [122], ACTA2 [123], SEMA3A [124], RARRES2 [125], CAV2 [126] and SPRED1 [127], but these genes might be novel target for GDM. The gene discussed is SPRED1; the disease is type 2 diabetes mellitus.