Based on the expression trend of hub genes in GDM, we found that UBE2D3 was the predicted target of hsa-mir-6127, HSP90AA1 was the predicted target of hsa-let-7d-5p, PAK2 was the predicted target of hsa-mir-8063, DDB1 was the predicted target of hsa-mir-329-3p, DVL3 was the predicted target of hsa-mir-1207-5p, FYN was the predicted target of hsa-mir-4651, ABL1 was the predicted target of hsa-mir-410-5p, SMAD3 was the predicted target of hsa-mir-222-3p, STAT3 was the predicted target of hsa-mir-29c-3p and PRKCA was the predicted target of hsa-mir-663a. The gene discussed is STAT3; the disease is gestational diabetes.