Finally, regarding the timing of these events in ovarian cancer, it is known that FOXM1 is expressed in HGSC precursor lesions in the FTE, which may, along with other proteins such as cyclin E1, increase RS, thus providing a selective advantage for RHNO1 co-expression (Karst et al., 2014; Levanon et al., 2014). The gene discussed is CCNE1; the disease is ovarian cancer.