FOXM1 and cancer: FOXM1 overexpression in HGSC and other cancers is driven by several mechanisms, including copy number gains, loss of function of p53 and pRB, activation of SP1, E2F1, and cyclin E1, and YAP signaling (Barger et al., 2019; Barger et al., 2015; Fan et al., 2015; Petrovic et al., 2010).