CLOCK and cancer: These tumor-suppressive effects may also correlate with repressing the transcription of Aldh3a1. However, further investigation is required to evaluate whether this CLOCK-induced ALDH suppression can be generalized to all types of cancer cells because the function of C/EBPα is altered by organs, differentiation state of cells, and transcriptional co-regulators (Lourenço and Coffer, 2017; Ossipow et al., 1993; Ramji and Foka, 2002).