Some pluripotent markers, such as Klf4, Nanog, and Myc, have important roles in maintenance of the undifferentiated state of cancer cells (Jeter et al., 2011; Lathia and Liu, 2017; Lawson et al., 2015; Yu et al., 2011), negatively correlated with treatment outcomes in cancer patients (Cheng et al., 2018; Dong et al., 2014; Elbadawy et al., 2019; Rasti et al., 2018). The gene discussed is KLF4; the disease is cancer.